Off-Label Use of Atypical Antipsychotics: An Update
Conclusions (3 of 3)
The risk of death in elderly patients (ages ≥65) is increased by both atypical and typical class antipsychotics. Adverse effects in both elderly and adult (ages 18–64) patients, not associated with age, include:
- Increased risk of weight gain: more common and severe with olanzapine
- Endocrine and metabolic abnormalities: risks are measurable but less certain
- Sedative effects, fatigue
- Extrapyramidal symptoms
The possibility of urinary adverse effects in elderly patients has appeared in studies of the atypical antipsychotics.
Keywords: antipsychotics | atypical antipsychotics | off-label | second generation | extrapyramidal symptoms | mortality | adverse effects | anorexia nervosa | substance abuse | sedation | fatigue | weight
- Maglione M, Ruelaz Maher A, Hu J, et al. Off-Label Use of Atypical Antipsychotics: An Update. Comparative Effectiveness Review No. 43 (Prepared by the Southern California RAND Evidence-based Practice Center under Contract No. HHSA 290-2007-10062-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11(12)-EHC087-EF. Available at www.effectivehealthcare.ahrq.gov/offlabelantipsych.cfm.
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