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Progestogens for Prevention of Preterm Birth

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Clinical Questions Addressed by the Comparative Effectiveness Review (1 of 2)

Although the use of progestogens to prevent preterm birth has been endorsed, there are still unanswered questions about their effectiveness and safety. Clinical questions addressed by the comparative effectiveness review included:

  • Does progestogen treatment—when compared with placebo, usual care, or other interventions—improve maternal or fetal/neonatal health outcomes?
  • What are the nature and frequency of maternal and child adverse effects of progestogen treatment?
  • How do effectiveness, adverse effects, and safety of progestogen treatment differ based on maternal risk factors for preterm birth?