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Noninvasive Technologies for Diagnosing Coronary Artery Disease in Women

Slide: 11 of 23

Clinical Questions Addressed by the Comparative Effectiveness Review (1 of 2)

In preparing the report on which this continuing medical education activity is based, the authors aimed to answer four key questions. Key Questions 1 and 2 are listed below:

Key Question 1: What is the accuracy of one noninvasive technology (NIT) in diagnosing obstructive and nonobstructive coronary artery disease (CAD) when compared with another NIT or with coronary angiography in women with symptoms suspicious for CAD?

  • Exercise ECG stress test, including resting ECG (e.g., multifunctional cardiogram)
  • Exercise/stress ECHO with or without a contrast agent
  • Exercise/stress radionuclide myocardial perfusion imaging, including SPECT and PET
  • CMR imaging
  • Coronary CTA

Key Question 2: What are the predictors of diagnostic accuracy (e.g., age, race/ethnicity, body size, heart size, menopausal status, functional status, stress modality) of different NITs in women?

CTA = computed tomography angiography; CMR = cardiac magnetic resonance imaging; ECG = electrocardiography; ECHO = echocardiography; PET = positron emission tomography; SPECT = single photon positron emission tomography