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Treatment for Hepatitis C Virus Infection in Adults: Comparative Effectiveness

Slide: 11 of 34

Clinical Questions Addressed by This Comparative Effectiveness Review (3 of 3)

This comparative effectiveness review attempted to address four key questions. Key Questions (KQs) 3 and 4 are listed on this slide:

KQ 3: This question has two parts:

a. What are the comparative harms associated with antiviral treatments?

b. Do these harms differ according to patient subgroup characteristics, including hepatitis C virus (HCV) genotype, age, race, sex, stage of disease, or genetic markers?

KQ4: Have improvements in intermediate outcomes (sustained virologic response; histologic changes) been shown to reduce the risk or rates of adverse health outcomes from HCV infection?