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Treatment for Hepatitis C Virus Infection in Adults: Comparative Effectiveness

Slide: 7 of 34

Background: Uncertainties Related to the Treatment of Chronic Hepatitis C Virus Infection in Adults

Decisions about treatment strategies for patients with chronic hepatitis C virus (HCV) infection who are treatment naïve are based on various factors, including:

  • Disease-related factors such as hepatitis C genotype, the presence of liver disease, and the severity of liver disease
  • Patient-related factors such as the presence of comorbidities and demographic characteristics
  • The continued development of new treatment strategies, including the testing of the all-oral interferon-sparing therapies that may be available in the coming years
  • An understanding of the comparative benefits and harms of dual and triple antiviral treatment regimens and whether they are affected by medication dose, treatment duration, and dosing strategy (fixed treatment vs. response-guided therapy), which is particularly important, given the availability of new treatment options (telaprevir and boceprevir) for chronic HCV infections