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Drug Therapy for Rheumatoid Arthritis in Adults

Slide: 13 of 45

Adverse Effects of Interest in the Comparative Effectiveness Review

For analysis of the clinical study evidence, reviewers focused on these adverse effects measurements:

  • Withdrawal due to adverse events
  • Time to withdrawal
  • Infusion and injection-site reactions
  • Infections
  • Malignancy
  • Mortality
  • Cardiovascular and cerebrovascular events
  • Rare but serious adverse events: demyelination, autoimmunity, pancytopenia, and hepatotoxicity