Drug Therapy for Rheumatoid Arthritis in Adults
Summary of Results: Head-to-head Comparisons of Combination Treatment With Oral DMARDs
Studies of oral disease-modifying anti-rheumatic drugs (DMARDs) include head-to-head comparisons of DMARDs used in combination and compared with monotherapy or other DMARD combinations. Patient populations included those with early rheumatoid arthritis who had not been treated with DMARDs, and those patients with longstanding active rheumatoid arthritis and inadequate response to treatment. The number of studies and patients examined is limited, but where available, the strength of evidence in support of the findings is moderate. Some outcomes were not reported in all studies.
Keywords: rheumatoid arthritis | RA | DMARDs | disease-modifying | antirheumatic | anti-rheumatic | rheumatic | biologic DMARD | oral DMARD | nonbiologic DMARD | early RA | methotrexate | sulfasalazine | hydroxychloroquine | disease activity | symptom response | radiographic progression | functional capacity
- Donahue KE, Jonas D, Hansen RA, et al. Drug Therapy for Rheumatoid Arthritis in Adults: An Update. Comparative Effectiveness Review No. 55 (Prepared by the RTI International–University of North Carolina Evidence-based Practice Center under Contract No. 290-2007-10056-I). Rockville, MD: Agency for Healthcare Research and Quality; April 2012. AHRQ Publication No. 12-EHC025-EF. Available at www.effectivehealthcare.ahrq.gov/dmardsra.cfm.
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