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Read Suggested Topics for Research

Browse or use the search box below to see suggestions submitted by others. Click on the text link to read the full suggestion. Suggestions are presented as they were submitted and are not edited. See Search for Guides, Reviews, and Reports for research in progress and final reports.

Suggestions that have completed the Program's selection process are identified by a topic suggestion disposition (PDF). Suggestions submitted prior to 2008 were reviewed under a different process and disposition reports may not be available.

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June 17, 2009

For patients with PKU, there is now a pharmaceutical drug to treat this condition. In the past is was treated by medical foods that eliminated the harmful substance phenylalanine. The cost of the new ...

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June 17, 2009

POCT Testing for HbA1c

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June 17, 2009

Sepsis biomarkers and their utility

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View Topic Suggestion Disposition (PDF) 104 kB

June 17, 2009

Serum free light chain analysis for the diagnosis

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June 13, 2009

What is the comparative effectiveness of training interdisciplinary healthcare personnel in a virtual, 3D, world versus a physical simulation laboratory? Is training in a virtual, 3D, world transferr ...

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June 1, 2009

For infants with exposure to general anesthesia who may have long term adverse neurodevelopmental outcome, what is the effectiveness of an alternate anesthetic technique of regional anesthesia?

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May 29, 2009

What are the Complementary and Alternative Medicine (CAM) treaments (supplements, including herbal formulations) that are helpful in reducing PSA levels associated with begnign prostatic hyperplasia ( ...

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May 24, 2009

Migraine patients in the ER receive various IV medications from different ER doctors within the physician group. As I have watched particular drug combinations given to my patients and to my daughter ...

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May 19, 2009

For patients with allergic disease, what is the comparative effectiveness of improving health outcomes and lowering healthcare utilization by treating their disease with sublingual immunotherapy (alle ...

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May 14, 2009

For newly diagnosed patients with open-angle glaucoma, what is the comparative effectiveness of medication versus laser surgery in controlling 24-hour intraocular pressure?

May 7, 2009

For children with newly diagnosed epilepsy, ketogenic diet treatment should be evaluated against traditional anti-seizure medication.

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May 4, 2009

Why are there no discussion on comparing the effectiveness of medical foods to phamaceuticals in the treatment of diseases in children? For example the effectiveness of the Ketogenic diet in children ...

Apr. 28, 2009

Does the implementation of a free standing personal health record for children with special health care needs improve: 1) clinical outcomes, 2)care coordination, 3) communication with providers and de ...

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Apr. 22, 2009

All therapy Effectiveness tests need to include compliance verification in order to ensure the validity of the test. For example a test comparing two drugs (in pill form) need to confirm that partici ...

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Apr. 22, 2009

1)DVT prophylaxis in special populations. 2)Comparative effectiveness between heparin and LWMH (low molecular weight heparins).

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Apr. 22, 2009

Multimodal Pain Management Programs vs. Single Therapies

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Apr. 21, 2009

Title: Prevention of venous thromboembolism (VTE) in orthopedic surgery. Set of related questions for considerationPICO-Question #1: In patients undergoing major orthopedic surgery (total hip and kn ...

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Apr. 20, 2009

compliance verification for medical devices and medications

Apr. 16, 2009

For patients with moderate to severe psoriasis, what is the comparative effectiveness of using etanercept (enbrel) versus methotrexate?

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Apr. 14, 2009

What is the comparative effectiveness of interventions for neovascular, age-related macular degeneration(AMD)?

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Apr. 10, 2009

For women, when comparing noninvasive testing,which testing method (echocardiography, MIBI-SPECT, pharmacological testing, etc.) is more accurate in diagnosing coronary artery disease. There has bee ...

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View Topic Suggestion Disposition (PDF) 114 kB

Apr. 9, 2009

In the area of autism research, the vast majority of clinical trials conducted to date have addressed only the questions of how an individual treatment compares to a placebo. Extremely few studies hav ...

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Apr. 8, 2009

For the estimated 70 million Americans with hypertension and the tens of millions more at risk, how would government regulations lowering sodium content in restaurant and processed foods compare to us ...

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Apr. 8, 2009

Comparative Effectiveness of Hydroxymethyl-glutaryl-coenzyme A-reductase (HMG CoA) Inhibitors in the Prevention of Neurodegenerative Disease, Septicemia, and Ventilator-associated Pneumonia

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Apr. 3, 2009

The comparative effectiveness of vasopressors, inotropes, and volume in the management of septicemia with hypotension. Population: patients with septicemia and hypotension Intervention/Comparators: ...

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