1.What is the evidence for the existence of febrile seizures i.e. seizures in which fever has a necessary and causal relationship to the seizures and therefore lowering the body temperature is sufficient to prevent the seizures 2.What is the evidence that acetaminophen reduces the attack rate of seizures in children with dengue3.What is the evidence that dengue does not increase the attack rate or severity of liver disease in children receiving acetaminophen4.What is the evidence that acetaminophen reduces fever in dengue5.What is the evidence that dengue virus replication is not inhibited by fever and therefore that antipyretics do not undermine a fundamental hostdefense mechanism OR can considerWhat is the comparative effectiveness benefits and harms of antipyretics in children with dengue Patients Children with dengueInterventions acetaminophen others e.g. NSAIDs ASAComparators other antipyretics placeboOutcomes seizure rates liver disease reduction in temperature viral replication

The topic is important because acetaminophen which can cause potentially fatal liver disease particularly in children is being actively promoted by CDCand the World Health Organization WHOas a standard component of therapy in for a disease that is increasing its global distribution.

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