1. What is the decision or change (e.g. clinical topic, practice guideline, system design, delivery of care) you are facing or struggling with where a summary of the evidence would be helpful?

Questions: What is the comparative effectiveness in reducing post-op opioid usage when Zynrelef was used for a choice of local anesthetics compared to Exparel ?
Population: Adults undergoing knee or hip replacement
Intervention: Zynrelef Vs. Exparel
Outcomes: Opioid Usage in Morphine Equivalent, Ambulation Distance both groups, Patient-Reported Outcome Measure (PROMs), such as, HOOS (Hip dysfunction and Osteoarthritis Outcome Score) and KOOS (Knee injury and Osteoarthritis
Setting: Surgery, Post-Op

2. Why are you struggling with this issue?

Zynrelef is relatively a new drug and there has been some evidence that Exparel has not lasted more than 72 hours in which the patients likely consumer more opioids to control the post-op pain.

3. What do you want to see changed? How will you know that your issue is improving or has been addressed?

Comparable data between Zynrelef and Exparel to identify opportunities to reduce opioid consumption.

4. When do you need the evidence report?

Wed, 01/01/2025

5. What will you do with the evidence report?

To guide healthcare decisions in the inpatient setting, possibly in a healthcare system. This also will be helpful if embedded in the practice guidelines.

Optional Information About You

What is your role or perspective? Clinical Pharmacy Manager

If you are you making a suggestion on behalf of an organization, please state the name of the organization Texas Health Huguley

May we contact you if we have questions about your nomination? Yes