The American College of Obstetricians and Gynecologists (ACOG) has released a clinical practice guideline on pregnancy and postpartum mental health conditions that used an AHRQ systematic review as an evidence base. ACOG’s June 2023 guideline on Treatment and Management of Mental Health Conditions During Pregnancy and Postpartum is based on AHRQ’s 2021 systematic review “Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacologic Interventions.” The guideline includes 14 recommendations on treatment and management of perinatal depression, anxiety, bipolar disorders, and acute postpartum psychosis, with a focus on psychopharmacotherapy. It includes three Good Practice Points to provide guidance when a formal recommendation cannot be made due to inadequate evidence. The guideline also outlines specific steps for initial and followup treatment of perinatal mental health conditions. It was reviewed by the Committee on Women's Mental Health of the American Psychiatric Association and endorsed by the Society for Maternal-Fetal Medicine.