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Health Outcomes of Biologic Agents for Metastatic Colorectal Cancer

Abstract ARCHIVED Jan 19, 2010

Page Contents

Topic Abstract

Background: Clinical trials support the efficacy of the biologic therapies cetuximab and bevacizumab for the treatment of metastatic colorectal cancer, but their real-world effectiveness in diverse populations has not been well evaluated.

Objective: To evaluate the effectiveness of the biologic therapies cetuximab and bevacizumab by studying the balance of benefits and harms of adding biologic therapy to standard CRC chemotherapy regimens treatments for CRC.

Study Design: Retrospective cohort study.

Methods: Data sources include cancer registries, the Medicare program, the National Cancer Center Network (NCCN), the National Cancer Institute’s Cancer Care Outcomes Research and Surveillance Consortium (CANCORS), and a phase IV industry sponsored registry. The study will examine both survival outcomes and the incidence of serious treatment complications such as hospitalization, major bleeding episodes, heart attacks and strokes. We will measure the size of the implementation gap (Efficacy-Effectiveness between trial and non-experimental data) not only for patients with attributes similar to clinical trial participants, but also for patients who were explicitly excluded from or underrepresented in the biologic treatment trials (e.g., old age, comorbidity). This knowledge can be used to prioritize new trials, refine practice guidelines and treatment recommendations and will provide stakeholders with a comprehensive understanding of the ramifications of integrating biologic therapy into the CRC cancer treatment armamentarium.

Expected Outputs: Scientific reports

Expected Project Completion Date: Fall 2011.

Project Timeline

Health Outcomes of Biologic Agents for Metastatic Colorectal Cancer

Jan 19, 2010
Topic Initiated
Jan 19, 2010
Abstract Archived
Page last reviewed December 2019
Page originally created November 2017

Internet Citation: Abstract: Health Outcomes of Biologic Agents for Metastatic Colorectal Cancer. Content last reviewed December 2019. Effective Health Care Program, Agency for Healthcare Research and Quality, Rockville, MD.

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