Topic Abstract
This pilot study will test the hypothesis that individual human genetic variation among persons with type 2 diabetes mellitus (DM) affects the clinical response to the oral hypoglycemic Metformin. Specifically, using a case-control study design, the study will assess how the variations in two single nucleotide polymorphisms of the Organic Cation Transporter 1 (OCT1) gene, and how the variation in a single nucleotide polymorphism of the Organic Cation Transporter 2 (OCT2) gene are associated with response to Metformin therapy in African-American and non-Hispanic white individuals with DM that have never taken Metformin.
