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A Case Control Study to Assess Association of Variations in OCT Genes with Effectiveness of Metformin in Diabetic Patients

Abstract ARCHIVED Jan 1, 2005

Topic Abstract

This pilot study will test the hypothesis that individual human genetic variation among persons with type 2 diabetes mellitus (DM) affects the clinical response to the oral hypoglycemic Metformin. Specifically, using a case-control study design, the study will assess how the variations in two single nucleotide polymorphisms of the Organic Cation Transporter 1 (OCT1) gene, and how the variation in a single nucleotide polymorphism of the Organic Cation Transporter 2 (OCT2) gene are associated with response to Metformin therapy in African-American and non-Hispanic white individuals with DM that have never taken Metformin.

Project Timeline

A Case Control Study to Assess Association of Variations in OCT Genes with Effectiveness of Metformin in Diabetic Patients

Jan 1, 2005
Topic Initiated
Jan 1, 2005
Abstract Archived
Page last reviewed December 2019
Page originally created November 2017

Internet Citation: Abstract: A Case Control Study to Assess Association of Variations in OCT Genes with Effectiveness of Metformin in Diabetic Patients. Content last reviewed December 2019. Effective Health Care Program, Agency for Healthcare Research and Quality, Rockville, MD.
https://effectivehealthcare.ahrq.gov/products/diabetes-metformin-oct-genes/abstract

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