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Effective Health Care Program

Comparative Effectiveness of Medications To Reduce Risk of Primary Breast Cancer in Women

Systematic Review

Archived: This report is greater than 3 years old. Findings may be used for research purposes, but should not be considered current.

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The purpose of this review is to evaluate the comparative effectiveness of tamoxifen citrate, raloxifene, and tibolone to reduce risk for primary breast cancer, assess the nature and magnitude of harms, and examine how benefits and harms vary by age, breast cancer risk status, and other factors. In addition, it examines issues related to clinical effectiveness, such as patient choice, concordance, adherence, and persistence of use, and evaluates methods to appropriately select patients for medication therapy to reduce risk of breast cancer.