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Effective Health Care Program

Comparative Effectiveness and Safety of Analgesics for Osteoarthritis

Systematic Review Archived

Archived: This report has been updated.

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The purpose of this report was to assess the comparative efficacy and safety of non-opioid oral medications (selective and non-selective non-aspirin NSAIDs, aspirin, salsalate, and acetaminophen), over-the-counter supplements (chondroitin and glucosamine), and topical agents (NSAIDs and rubefacients, including capsaicin) for osteoarthritis.