Skip to main content
Effective Health Care Program

Comparative Effectiveness and Safety of Oral Diabetes Medications for Adults With Type 2 Diabetes

Systematic Review Archived

Archived: This report has been updated.

People using assistive technology may not be able to fully access information in this file. For additional assistance, please contact us.


We have performed a systematic review of published studies on the comparative effectiveness and safety of all oral diabetes medications. By comparing the short-term and long-term clinical effects of these medications, clinicians may have a better sense of how to choose among the oral diabetes medications. This review should be helpful as new classes of oral diabetes medications come on the market, such as the dipeptidyl peptidase-IV (DPP-IV) inhibitors. In addition, the results presented here may provide policymakers and insurers with better insight as they consider policies relating to medication coverage