1. What is the decision or change (e.g., clinical topic, practice guideline, system design, delivery of care) you are facing or struggling with where a summary of the evidence would be helpful?
What is the effectiveness of the CRISPR-Cas9 gene editing process against ADHD patients with risk genes that are more on the hereditary side. The goal would be to find substantial evidence fixing the DRD4 gene found in ADHD gene makeup for most of the effected population. The study would use CRISPR-Cas9 to edit the DRD4 gene which affects the efficiency that dopamine is produced in different parts of the brain in the ADHDs population. In writing the idea is interesting and great question however with costs of CRISPR-Cas9 and clinical studies the possibility of this study and variations of this study in my eyes is difficult to justify.
2. Why are you struggling with this issue?
After some time spent researching, no studies or clinical trails give information showing possible or effectives of the CRISPR-Cas9 edit of the DRD4 gene. This is very specific so it’s understandable why this idea has not been clinically trialed yet. Some articles point to possible effective treatment using CRISPR-Cas9 to treat the ADHD population but nothing that gets more specific.
3. What do you want to see changed? How will you know that your issue is improving or has been addressed?
A future where someone with ADHD is able to receive affordable gene treatment that has life long benefits.
5. What will you do with the evidence report?
I would use the evidence given to better understand where the current reliability and possible long-term treatments of ADHD are standing. This helps me and many others as the tools used for ADHD are under studied or based on partial evidence of working treatment. Speaking for many people with ADHD, the known treatments are few with the widely accepted mainly being CBT (Cognitive Behavioral Therapy, I say this because medication has always been disputed and has further research to be done. I am in no means disputing the idea that medication for ADHD is not worth it, i am shedding light on the research shown that the evidence is only half there. People with ADHD should still seek treatment in medication if that's the best option however it should be noted that medication may not work for everyone.
Optional Information About You
What is your role or perspective? ADHD Patient
May we contact you if we have questions about your nomination? No
