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Comparative effectiveness for the treatment of major depressive disorder (MDD) Key questions: 1. For the treatment of MDD, what is the comparative effectiveness of SSRIs, placebo, psychotherapy, exercise, and alternative therapies? 2. For…

NOMINATED TOPIC | March 11, 2013
Briefly describe a specific question, or set of related questions, about a health care test or treatment that this program should consider.

Comparative effectiveness for the treatment of major depressive disorder (MDD) Key questions:

  1. For the treatment of MDD, what is the comparative effectiveness of SSRIs, placebo, psychotherapy, exercise, and alternative therapies?
  2. For the treatment of MDD, what is the effectiveness of SSRIs in combination with psychotherapy, exercise, and alternative therapies?
  3. What are the harms and benefits of non-pharmacologic therapies for the treatment of MDD?
  4. Are there patient subgroups (e.g. by age, sex, race/ethnicity) who are more or less likely to benefit from these different treatment options?
Does your question include a comparison of different health care approaches? (If no, your topic will still be considered.)

yes

If yes, explain the specific technologies, devices, drugs, or interventions you would like to see compared:
What patients or group(s) of patients does your question apply to? (Please include specific details such as age range, gender, coexisting diagnoses, and indications for therapy.)
Are there subgroups of patients that your question might apply to? (For example, an ethnic group, stage or severity of a disease.)
Describe the health-related benefits you are interested in. (For example, improvements in patient symptoms or problems from treatment or diagnosis.)
Describe any health-related risks, side effects, or harms that you are concerned about.

Appropriateness for EHC Program

Does your question include a health care drug, intervention, device, or technology available (or likely to be available) in the U.S.?

yes

Which priority area(s) and population(s) does this topic apply to? (check all that apply)
EHC Priority Conditions (updated in 2008)
  • Depression and other mental health disorders
AHRQ Priority Populations
None
Federal Health Care Program
None

Importance

Describe why this topic is important.
What specifically motivated you to ask this question? (For example, you are developing a clinical guideline, working with a policy with large uncertainty about the appropriate approach, costly intervention, new research you have read, items in the media you may have seen, a clinical practice dilemma you know of, etc.)
Does your question represent uncertainty for clinicians and/or policy-makers? (For example, variations in clinical care, controversy in what constitutes appropriate clinical care, or a policy decision.)

yes

If yes, please explain:

Potential Impact

How will an answer to your research question be used or help inform decisions for you or your group?
Describe the timeframe in which an answer to your question is needed.
Describe any health disparities, inequities, or impact on vulnerable populations your question applies to.

Nominator Information

Other Information About You: (optional)
Please choose a description that best describes your role or perspective: (you may select more than one category if appropriate)
Are you making a suggestion as an individual or on behalf of an organization?

Organization

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Project Timeline

Nonpharmacological Versus Pharmacological Treatments for Adult Patients With Major Depressive Disorder

Feb 3, 2014
Topic Initiated
Jun 19, 2014
Dec 8, 2015
Sep 13, 2016
Sep 13, 2016
Consumer Summary Archived
May 9, 2017
Consumer Summary Archived
Page last reviewed November 2017
Page originally created March 2013

Internet Citation: Comparative effectiveness for the treatment of major depressive disorder (MDD) Key questions: 1. For the treatment of MDD, what is the comparative effectiveness of SSRIs, placebo, psychotherapy, exercise, and alternative therapies? 2. For…. Content last reviewed November 2017. Effective Health Care Program, Agency for Healthcare Research and Quality, Rockville, MD.
https://effectivehealthcare.ahrq.gov/get-involved/nominated-topics/comparative-effectiveness-for-the-treatment-of-major-depressive-disorder-mdd-key-questions-1-for-the-treatment-of-mdd-what-is-the-comparative-effectiveness-of-ssris-placebo-psychotherapy-exercise-and-alternative-therapies-2-

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