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Is there myocardial involvement in patients with statin induced myopathy?

NOMINATED TOPIC | November 29, 2009
Briefly describe a specific question, or set of related questions, about a health care test or treatment that this program should consider.

Is there myocardial involvement in patients with statin induced myopathy?

Does your question include a comparison of different health care approaches? (If no, your topic will still be considered.)

no

If yes, explain the specific technologies, devices, drugs, or interventions you would like to see compared:
What patients or group(s) of patients does your question apply to? (Please include specific details such as age range, gender, coexisting diagnoses, and indications for therapy.)

Any patient on statin therapy.

Are there subgroups of patients that your question might apply to? (For example, an ethnic group, stage or severity of a disease.)
Describe the health-related benefits you are interested in. (For example, improvements in patient symptoms or problems from treatment or diagnosis.)

Statin induced myopathy is thought to be limited to skeletal muscle. If cardiac muscle is also involved the implications are much more significant. Furthermore, asymptomatic statin induced myopathy might very well include cardiac muscle as well.

Describe any health-related risks, side effects, or harms that you are concerned about.

Appropriateness for EHC Program

Does your question include a health care drug, intervention, device, or technology available (or likely to be available) in the U.S.?
Which priority area(s) and population(s) does this topic apply to? (check all that apply)
EHC Priority Conditions (updated in 2008)
  • Cardiovascular disease, including stroke and hypertension
AHRQ Priority Populations
None
Federal Health Care Program
None

Importance

Describe why this topic is important.

Statins are widely prescribed medications and statin induced myopathy is a common complication. What is notknown, or appreciated, is if statins also cause cardiomyopathy.

What specifically motivated you to ask this question? (For example, you are developing a clinical guideline, working with a policy with large uncertainty about the appropriate approach, costly intervention, new research you have read, items in the media you may have seen, a clinical practice dilemma you know of, etc.)
Does your question represent uncertainty for clinicians and/or policy-makers? (For example, variations in clinical care, controversy in what constitutes appropriate clinical care, or a policy decision.)
If yes, please explain:

Potential Impact

How will an answer to your research question be used or help inform decisions for you or your group?
Describe the timeframe in which an answer to your question is needed.
Describe any health disparities, inequities, or impact on vulnerable populations your question applies to.

Nominator Information

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Page last reviewed November 2017
Page originally created November 2009

Internet Citation: Is there myocardial involvement in patients with statin induced myopathy?. Content last reviewed November 2017. Effective Health Care Program, Agency for Healthcare Research and Quality, Rockville, MD.
https://effectivehealthcare.ahrq.gov/get-involved/nominated-topics/is-there-myocardial-involvement-in-patients-with-statin-induced-myopathy

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