1. What is the decision or change (e.g., clinical topic, practice guideline, system design, delivery of care) you are facing or struggling with where a summary of the evidence would be helpful?

1. In persons with thyroid dysfunction, what are the benefits and harms of thyroid supplements like desiccated thyroid hormone or T3 supplements compared with levothyroxine?

Population: Persons with thyroid dysfunction
Intervention: thyroid supplements (e.g. desiccated thyroid hormone, T3 supplements, OTC supplements)
Comparison: levothyroxine
Outcomes: Quality of life (including sleep quality, anxiety/depression, mood), weight loss/gain, cognitive function, adverse events such as atrial fibrillation, osteoporosis or bone loss.

2. In persons with thyroid dysfunction, what is the effectiveness of interventions combatting misinformation or disinformation?

Population: Persons with thyroid dysfunction
Intervention: educational interventions addressing mis- or disinformation
Comparison: no intervention
Outcomes: patient awareness/understanding, anxiety/depression, symptom management
 

3. Why are you struggling with this issue?

Around 20 million people in the U.S. have a thyroid condition—many of whom are not aware. Misinformation is a growing concern in evidence-based medicine, particularly in thyroid care as supplements like desiccated thyroid hormone are available without a prescription but have limited evidence supporting their use.

4. What do you want to see changed? How will you know that your issue is improving or has been addressed?

Increased patient and clinician awareness of the efficacy of thyroid supplements compared to levothyroxine would be an indication of improvement in this area.

5. When do you need the evidence report?

Thu, 12/31/2026

6. What will you do with the evidence report?

An updated evidence review on the benefits and harms of thyroid supplements in addition to potential interventions aimed at combatting misinformation would be beneficial in the development of guidance for healthcare professionals and patients. AACE plans to update guidelines on hypothyroidism and hyperthyroidism in the next few years (2026-2027).

Optional Information About You

What is your role or perspective? Professional society

If you are you making a suggestion on behalf of an organization, please state the name of the organization American Association of Clinical Endocrinology

May we contact you if we have questions about your nomination? Yes