Treatment for Depression

NOMINATED TOPIC | August 23, 2021

Treatment for Depression

1. What is the decision or change you are facing or struggling with where a summary of the evidence would be helpful?

I am someone you responds well to Serotonin Medications esp. SSRI's for depression. I am 48 years old and I am struggling greatly. I have been on all the SSRI's and they eventually stop working for me. Usually tied to a stressful lose of a number of relatives within one month lose of relationship and added stressors. Paxil lasted 2 y.o. celexa 1 month Luvox 1 month prozac lasted 15 y.o. got my BBA Degree and later my Masters Degree worked for about 7 years as a Counselor for a non-profit Mental Health Agency to help others with mental health issues then the losses of relative came and added stress and the Medication stopped working. I tried Zoloft worked 9 months and stopped.  Viibryd worked almost a year. Trintellex one month.  Then tried Anafrinal TCA(SRI) six months no help up and down two days ok two crying. Then Cymbolta worked 1 week keep tring cried everyday.  Effexor did not help even with Remoron. What has the highest Serotonin level medications left to try? I am trying Doxepin.

2. Why are you struggling with this issue?

How to Raise my Serotonin levels with other medications available and stop the suicidal thoughts. Use to stop the suicidal thoughts after 3 weeks on an SSRI or Serotonin based medication. Struggling do not want to live like this need to find a way to lift the suicidal thoughts. I have been in and out of hospitals and do not want to hurt my family just want the pain of Depression to go away especially the suicidal thoughts. Please help.

3. What do you want to see changed? How will you know that your issue is improving or has been addressed?

My Depression to lift. I w lose the suicidal thoughts and start to feel positive thoughts and out going like my usual self. To be high functioning and into activities and being social. Please Help me.

4. When do you need the evidence report?

Tue, 09/21/2021

5. What will you do with the evidence report?

Find a medication to help improve the ability to lift the Depression or supplements to improve Serotonin levels to lift depression. Any new Serotonin medication in clinical trials? OR available in other countries info on Tianeptine SSRE Deep Brain Stimulation for Depression and does it increase levels of Serotonin in the Brain. Also Think I have Pure O. A type of OCD with mostly Obsessive thought like a broken record usually tied to negative thing (depression related). Is there any evidence that Deep Brain Stimulation for OCD and Depression can be combined to customize the results of reduce O in OCD and Depression. In DBS for OCD any evidence it increases serotonin levels. I have found best out comes are with SSRI type medication or medications that increases serotonin levels and Therapy with CBT and DBT treatment combined.

(Optional) About You

What is your role or perspective? Patient/Consumer

If you are you making a suggestion on behalf of an organization, please state the name of the organization: N/A

May we contact you if we have questions about your nomination? Yes

Page last reviewed September 2021
Page originally created August 2021

Internet Citation: Treatment for Depression. Content last reviewed September 2021. Effective Health Care Program, Agency for Healthcare Research and Quality, Rockville, MD.

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