1. Your Nomination - Please briefly describe in your own words the question about a health care test or treatment that interests or concerns you:

What are the medication combinations for treatment of dyspilidemia when a single medication does not achieve recommended lipid values?

2. Why do you think your question is important? (you may select more than one category if appropriate)

 My question relates to a very common disease or problem
 People with this disease or problem have considerable health or financial hardships
 There is uncertainty about how well the test, treatment, or intervention works
 There is significant potential for side effects/harms using this test, treatment, or intervention
 Funding of this test, treatment, or intervention is uncertain or variable
 There is unequal access or application of this health care intervention across providers
 There is potential for cost savings from better information on this subject
 This is a new technology/development
 There is new evidence of clinical and/or cost effectiveness for this test, treatment, or intervention
 Other

3. What illness or health condition is related to your question? (You can also specify a particular health-promoting activity, such as breast-feeding)

Dyslipidemia in adults.

4. What group(s) or patients does your question apply to?

Adults with dyslipidemia who do not acheive therapeutic targets on one medication.

5. What is the specific purpose of the health care test or treatment you have a question about? (mark all that you think apply)

Identification of a disease or condition:
 Screening or diagnosis/identification for a particular disease, or risk assessment for a disease
 Risks or harms that can come from a disease identification tool or test
 Diagnostic tests and tools
 Diagnosis of co-occurring diseases
 Intervention (such as a drug treatment, therapy, device)
 Management of a condition or particular system of care
 Delivery of a health service
 Referral
 Risks or harms associated with treatment of a disease or condition
 Prevention or health promotion
 Specific population health concerns, such as ethnic group or gender
 Other
 Dont know

6. Does your question include a comparison of different health care approaches?

No
If yes, please list what you would like to see compared:

7. Desired Health Improvements: If you question focuses on:

Identification of a particular disease or condition, what improvements in identification or diagnosis would you like to see?


Treatment of a particular disease or condition, what improvements in patient symptoms or problems would you like to see? Improved control of dyslipidemia by more effective combinations.

8. Harms: Are there risks, side effects, or harms you are concerned about? If yes, please specify what those are:

Two or more medication combinations for the treatment of dyslipidemia has potential for adverse drug reactions and drug-drug interactions. What is the evidence for harms and benefits of different possible combinations?

9. Based on your answers to the previous questions, what research question(s) would you like to have answered?

What is the evidence for harms and benefits of different possible combinations for the treatment of dyslipidemia when a single medication is not effective on its own?

10. Are there health-care focused, disease-focused, or patient-focused organizations that you see as being relevant to this issue? Who do you think we should contact as we consider your nomination?

11. Other Information About You (OPTIONAL) In order to help us understand the context of your health care question, it would be helpful to know more about you. The answers you give will not influence the progress of your suggestion. Thank you.

a. Please choose a description that best describes your role or perspective: (you may select more than one category if appropriate)
Physician

b. Is there any other information about you that is relevant to your question?


c. Are you making a suggestion as an individual or on behalf of an organization?
 Individual
 Organization